Quinolines and derivatives
![Medchemexpress LLC Ethanesulfonic acid, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]- | 1817735-43-5 | 99.5% | 257.30 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Ethanesulfonic acid, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]- | 1817735-43-5 | 99.5% | 257.30 | 25 MG
Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to a target protein. They function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Intended for research use only
- Appearance: oil, colorless to light yellow
- Target: PEGs
- Storage: -20°C under nitrogen
Medchemexpress LLC Etravirine | 269055-15-4 | MFCD09837879 | 99.1% | C20H15BrN6O | 200 MG
Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and a potent antiviral drug primarily used in the treatment of human immunodeficiency virus (HIV) type 1 infection. It is effective against various strains of HIV-1, including those resistant to other NNRTI treatments. This product is intended for research use only.
- Targets HIV-1 and HIV-2
- Inhibits non-nucleoside reverse transcriptase
- Effective against resistant HIV-1 strains
- Suitable for research applications
![Medchemexpress LLC 1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo- | 1262417-51-5 | 99.5% | 395.42 | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000385759-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo- | 1262417-51-5 | 99.5% | 395.42 | 200 MG
NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor for cancer therapy. It is for research use only and not sold to patients.
- Potent PARP-1 inhibitor (Kd=0.009 μM) with 150-fold selectivity over PARP-2 (Kd=1.39 μM).
- Less myelotoxic in vitro compared to olaparib.
- Metabolically stable.
- Modestly inhibits CYP-2B6 (IC50: 8.15 μM) and CYP-2D6 (IC50: 9.51 μM) out of eight isoforms tested.
- Possesses excellent pharmacokinetic profile and nearly complete oral bioavailability in mice and rats.
- Highly efficacious in vivo as a single agent in MDA-MB-436 human breast cancer tumors and in combination with temozolomide in CAPAN-1 human pancreatic tumors.
- Well tolerated at highly efficacious doses and has an excellent ADME profile.
Apexbio Technology LLC Nutlin-3a chiral 675576-98-4 200mg
Nutlin-3a chiral (CAS 675576-98-4) is a small-molecule antagonist targeting mouse double minute 2 (MDM2) which functions as a negative regulator of the tumor suppressor TP53 By binding directly to the TP53-interacting pocket of MDM2 Nutlin-3a blocks the degradation of TP53 stabilizing the protein and activating TP53-dependent pathways Studies in solid tumors and lymphomas indicate that Nutlin-3a induces cell cycle arrest growth inhibition and apoptosis Research has demonstrated antitumor activity in vitro and in vivo highlighting its utility in studying TP53-related cell signaling pathways and its potential in cancer research applications
Medchemexpress LLC Afalanine (N-Acetyl-DL-phenylalanine) | 2901-75-9 | 99.9% | 200 MG
Afalanine (N-Acetyl-DL-phenylalanine) is an endogenous metabolite of an endophytic fungus with antidepressant activity. It can be used in combination with antibiotics to prevent renal damage.
- Endogenous metabolite of an endophytic fungus
- Antidepressant activity
- Can be used in combination with antibiotics to prevent renal damage
- For research use only
Medchemexpress LLC Guanidinoethyl sulfonate (Standard) | 543-18-0 | 99.9% | 167.19 | 10 MG
Guanidinoethyl sulfonate (Standard) | 543-18-0 | 99.9% | 167.19 | 10 MG
Medchemexpress LLC Vactosertib | 1352608-82-2 | 99.5% | 399.42 | 200 MG
Vactosertib (EW-7197) is a potent, orally active, and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor. It inhibits ALK2 and ALK4 at nanomolar concentrations and exhibits potent antimetastatic activity and anticancer effects. With a high purity of 99.53% and molecular weight of 399.42, this solid, off-white to yellow compound is a valuable tool for cancer research.
- Potent and orally active ALK5 inhibitor
- Inhibits ALK2 and ALK4
- Shows antimetastatic and anticancer effects
- Blocks TGFβ-induced phosphorylation of Smad2 or Smad3
- Suppresses TGFβ-induced nuclear translocation of Smad2/3
- Abrogates TGFβ1-induced tumor cell migration and invasion
- Abolishes TGFβ1-induced effects on genes related to epithelial-to-mesenchymal transition
Medchemexpress LLC Deucravacitinib | 1609392-27-9 | 99.9% | 425.46 | 200 MG
Deucravacitinib is a highly selective, orally bioavailable allosteric TYK2 inhibitor designed for the treatment of autoimmune diseases. It works by selectively binding to the TYK2 pseudokinase (JH2) domain, which blocks receptor-mediated Tyk2 activation by stabilizing its regulatory JH2 domain. This action inhibits IL-12/23 and type I IFN pathways. It is used for studying moderate to severe plaque psoriasis.
- Highly selective, orally bioavailable allosteric TYK2 inhibitor
- Designed for the treatment of autoimmune diseases
- Selectively binds to the TYK2 pseudokinase (JH2) domain
- Blocks receptor-mediated Tyk2 activation
- Inhibits IL-12/23 and type I IFN pathways
- Used for studying moderate to severe plaque psoriasis
- FDA's first de novo deuterium
Medchemexpress LLC Nilotinib | 641571-10-0 | 99.9% | 529.52 | 200 MG
Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity, designed for research use. It exhibits significant inhibitory effects against Bcr-Abl and various other targets, making it suitable for studies on cell proliferation and cytotoxicity.
- Exhibits antiproliferative activity in A549 cells with an IC50 of 6.63 μM.
- Shows antiproliferative activity in BJ cells with an IC50 of 12.8 μM.
- Inhibits various BCR/ABL p210 mutants (GI50 0.004 μM to > 10 μM).
- Induces cytotoxicity against various BaF3 cell lines.
- Used in CCK-8 assays for IC50 assessment in liver cancer cell lines.
- Useful for observing anti-colony formation effects.
- Utilized for immunohistochemistry of primary tumors.
- Investigated for its direct effect on cytotoxic lymphocytes.
- Applied for cell cycle analysis.
Medchemexpress LLC Molnupiravir | 2492423-29-5 | 99.9% | 329.31 | 200 MG
Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. It exhibits broad-spectrum antiviral activity against influenza virus and multiple coronaviruses, including SARS-CoV-2, MERS-CoV, and SARS-CoV. It is being researched for its potential use in COVID-19 and seasonal/pandemic influenza.
- Orally bioavailable prodrug
- Exhibits broad-spectrum antiviral activity
- Effective against SARS-CoV-2, MERS-CoV, and SARS-CoV
- Being researched for use in COVID-19 and influenza
- Prevents SARS-CoV replication in C57BL/6 mice
- Reduces shed virus load and fever duration in ferrets
Medchemexpress LLC Pictilisib (dimethanesulfonate) | 957054-33-0 | 99.7% | 705.85 | 200 MG
Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
- Potent inhibitor of PI3Kα/δ with IC50 of 3 nM
- Modest selectivity against p110β (11-fold) and p110γ (25-fold)
- Reduces tumor cell viability in breast cancer cell lines
- Inhibits Akt phosphorylation and downstream targets of Akt signaling
- Shows high efficacy of antitumor activity in ZD1839-resistant non-small cell lung cancer (NSCLC) cell lines (A549 and H460)
- Highly efficacious in combination with U0126 in inducing cell growth inhibition, G0-G1 arrest, and cell apoptosis
- Reduces secreted VEGF after hypoxic/anoxic exposure
- Leads to tumor stasis in animal models
- Results in tumor regressions during treatment leading to enhanced antitumor responses
- Reduces tumor growth and PI3K and HIF-1 pathway activity in tumor-bearing mice
Medchemexpress LLC Palmitoylethanolamide | 544-31-0 | MFCD00020562 | 99.86% | 299.49 | 200 MG
Palmitoylethanolamide (Standard) is the analytical standard for Palmitoylethanolamide, an active endogenous compound. It is intended for research and analytical applications, and can be used for preventing virus infection of the respiratory tract.
- Analytical standard for Palmitoylethanolamide.
- Intended for research and analytical applications.
- Can be used for preventing virus infection of the respiratory tract.
- High purity of 99.86%.
- Available in multiple quantities for various research needs.
- Suitable for qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
Medchemexpress LLC Branaplam | 1562338-42-4 | 98.90% | 393.48 | 200 MG
Branaplam is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. It inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- Highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator.
- Elevates full-length SMN protein.
- Extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- EC50 of 20 nM for SMN.
- IC50 of 6.3 μM for hERG.
Medchemexpress LLC ASP-9521 | 1126084-37-4 | 98.0% | 330.42 | 200 MG
ASP-9521 is a potent, selective, and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3. It shows more than 100-fold selectivity for AKR1C3 over the isoform AKR1C2. This inhibitor suppresses AD-dependent PSA production and cell proliferation in LNCaP-AKR1C3 cells, and inhibits AD-induced intratumoural T production in CWR22R xenografts for up to 24 hours.
- Potent and selective AKR1C3 inhibitor
- Orally available
- High selectivity over AKR1C2
- Suppresses AD-dependent PSA production and cell proliferation
- Inhibits AD-induced intratumoural T production
- Inhibitory effect maintained for 24 hours